Citation: Yao Dong HUANG, Xiao Jie ZHANG, Ze Xu WANG, Fen Er CHEN. An Improved Synthesis of Retinoic Acid from β-Ionone[J]. Chinese Chemical Letters, ;2003, 14(1): 29-31. shu

An Improved Synthesis of Retinoic Acid from β-Ionone

Department of Chemistry, Fudan University, Shanghai 200433

Received Date: 3 April 2002

A convenient and large-scale preparation of rctinoic acid 1 from β-ionone in five steps with 38% overall yield is described. The key steps are the epoxidization of 2 with a new methylated agent and the condensation 4 with tetraethyl methylenediphophonate in one-pot procedure to prepare 6.
- Retinoic acid,
- trimethylsulfonium p-tolenesulfonate,
- allylic phosphonatc,
- Wittig-Horner-Emmons (WHE) reaction,
- synthesis
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