Citation: Bin YANG, Hou Li JIANG, Zhen Kai DING, Qi Kai ZHANG. Secondary Structure in Solution of an Analog of Salmon Calcitonin:[Val¹, Ala⁷]sCT[J]. Chinese Chemical Letters, ;1999, 10(7): 555-558. shu

Secondary Structure in Solution of an Analog of Salmon Calcitonin:[Val¹, Ala⁷]sCT

1.
Beijing Institute of Pharmacology and Toxicology Beijing 100850;
2.
National Center of Biomedical Analysis, Beijing 100850

Received Date: 26 January 1999

Secondary structure of [Val¹, Ala⁷]sCT, an analog of salmon caleitonin (sCT) not containing an N-terminal disultide bridge. was investigated by circular dichroism (CD) and Fourier-transform infrared spectroscopy (FTIR) methods. Both CD and FTIR results show that the main conformational structure of [Val¹, Ala⁷]sCT in aqueous solution is random coil structure while in trifluorethanol (TFE) it displays a strong α-helical structure. The relationship between the biological activity and the conformational structure of [Val¹, Ala⁷]sCT is also discussed.
- Salmon calcitonin analog,
- CD,
- FTIR,
- peptide secondary structure
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