Citation: Shi Hua PENG, Tong Hui ZHOU. THE STUDY ON IN VITRO METABOLISM OF BUTYLPHTHALIDE BY GAS CHROMATOGRAPHY－MASS SPECTROMETRY[J]. Chinese Chemical Letters, ;1995, 6(1): 55-58. shu

THE STUDY ON IN VITRO METABOLISM OF BUTYLPHTHALIDE BY GAS CHROMATOGRAPHY－MASS SPECTROMETRY

Institute of Materia Medica, Chinese Academy of Medical Sciences Beijiug 10O050

Received Date: 7 November 1994

Fund Project: This work was supported by the National Natural Science Foundation of China. The authors are grateful to Prof. Lixing Xu and Yipu Feng for providing the compound.

The in vitro metabolism o.butylphthalide (HBP) by rat liver microsomes was studied in this paper.Capillary GC/MS and BSTFA/1%TMCS derivatization were used for the separation and structure identification of the six metabolites.3-Hydroxylation and r-hydroxylation have been proved to be the main metabolism pathways of HBP by rat liver microsomes.
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