Citation: Bao Kun ZHU, Hong Bin ZHANG, Yu Shun ZHANG, Hui Min ZHONG, Jian Ping LIU. Oxidation of Hecogenin and Diosgenin Derivatives with Dimethyldioxirane[J]. Chinese Chemical Letters, ;2005, 16(2): 143-146. shu

Oxidation of Hecogenin and Diosgenin Derivatives with Dimethyldioxirane

1.
The School of Pharmacy, Center for Advanced Studies of Medicinal and Organic Chemistry, Yunnan University, Kunming 650091;
2.
The School of Chemistry, Qingdao Sci. & Techn. Univ., Qingdao 266042

Received Date: 17 December 2003

Diacetyl derivative of hecogenin 1 was oxidized to unsaturated ketone 5 via allylic alcohol 3 when it reacted with dimethyldioxirane (DMDO). The structure of 3 was confimed by X-ray crystal analysis and the highly regioselectivity of DMDO to different olefin bonds was also observed when diosgenin derivative 6 was treated with DMDO.
- Oxidation,
- dimethyldioxirane,
- hecogenin,
- diosgenin,
- derivative.
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