Citation: Xiang Hong LI, Rong WAN, Yu Fen ZHAO. The Hydrolysis of RNA by Histidine[J]. Chinese Chemical Letters, ;1997, 8(4): 299-302. shu

The Hydrolysis of RNA by Histidine

Bio-organic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100084

Received Date: 7 January 1997

Fund Project: The authors wish to acknowledge the financial support from the National Natural Science Foundation of China, the National Science and Technology Committee. We also thank Prof. Su Tian-sheng at the Chemistry Institute of Chinese Academy for offering the anion-exchange column.

The cleavage activity of histidine on RNA and DNA was tested.It was found that histidine could cleave RNA,but not DNA.The cleavage mechanism was proposed to be involved in the hydrolysis of the phosphodiester backbone.
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