Citation: Jian Bin LUO, Qiang WANG, Hong TAN, Jie Hua LI, Yin Ping ZHONG. Synthesis and Antimicrobial Properties of the Novel Fluorinated Bis-ammonium Salts with Two Primary Amine Groups[J]. Chinese Chemical Letters, ;2006, 17(11): 1423-1426. shu

Synthesis and Antimicrobial Properties of the Novel Fluorinated Bis-ammonium Salts with Two Primary Amine Groups

1.
College of Polymer Science and Engineering, Sichuan University, Chengdu 610065;
2.
College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041;
3.
Key Laboratory of Bio-resources and Eco-environment(Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610064

Received Date: 15 May 2006

In order to resolve the increasing resistance phenomena of the Gram-negative bacteria against single chain quaternary ammonium salts (QAS), lysine with a pedant fluorinated bis-ammonium salts was synthesized and its antimicrobial properties were evaluated in this work.The novel fluorinated bis-ammonium salts shows similar activity with conventional single chain quaternary ammonium salts against Gram-positive bacteria but stronger activity against Gram-negative bacteria and yeast compared with the single chained counterpart.
- Antimicrobial agents,
- fluorinated bis-ammonium salts,
- primary amine groups
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