Citation: Zhi Bin XU, Zong Ru GUO. An Abnormal Reaction of N-(2,4-dinitrophenyl)-L-proline with Thionyl Chloride[J]. Chinese Chemical Letters, ;2003, 14(2): 133-134. shu

An Abnormal Reaction of N-(2,4-dinitrophenyl)-L-proline with Thionyl Chloride

Zhi Bin XU ,
Zong Ru GUO

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 15 April 2002

N-(2,4-Dinitrophenyl)-4-amino-n-butyl aldehyde 3 was obtained with high yield of 80% when N-(2,4-dinitrophenyl)-L-proline 1 reacted with SOCl₂ at room temperature.However, the anticipated product N-(2,4-dinitrophenyl)-tetrahydropyrrolyl-2-(4-methylthiophenyl) ketone 2 did not be produced.The mechanism was discussed in this article.
- L-Proline,
- 1-fluoro-2,4-dinitrobenzene(FDNB),
- N-(2,4-dinitrophenyl)-4-amino-n-butylaldehyde
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