Citation: Tao WU, Shang Jie XU, Jian Quan SHEN, Shen CHEN, Man Hua ZHANG, Tao SHEN. Synthesis of demethoxy-amino-substituted hypocrellins:novel photosensitizers for photodynamic therapy[J]. Chinese Chemical Letters, ;2000, 11(11): 963-966. shu

Synthesis of demethoxy-amino-substituted hypocrellins:novel photosensitizers for photodynamic therapy

Tao WU ^1,2 ,
Shang Jie XU ^1,2 ,
Jian Quan SHEN ^1,2 ,
Shen CHEN ^1,2 ,
Man Hua ZHANG ^1,2 ,
Tao SHEN ^1,2

1.
Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080;
2.
Present mailing address:Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing 100101

Received Date: 24 April 2000

Fund Project: This work was supported by the National Natural Science Foundation of China. (No. 29772035 and 29872038)

A novel method was used to obtain demethoxy-amino-substituted hypocrellin derivatives. Peri-hydroxylated perylenequinone structure of hypocrellin was reserved when hypocrellin reacted with an amine in pyridine. The products were new compounds with significant cytotoxicity against tumor cells. Their structures have been established on the basis of their mass and ¹H NMR spectra.
- Hypocrellin,
- perylenequinone,
- photodynamic therapy,
- photosensitizer
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