Citation: Rong Min WANG, Jing Feng SONG, Yu Feng HE, Juan Juan MAO, Yan LI. Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin[J]. Chinese Chemical Letters, ;2006, 17(11): 1495-1498. shu

Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin

Key Laboratory of Polymer Materials of Gansu Province, Institute of Polymer, Northwest Normal University, Lanzhou 730070

Received Date: 4 September 2006

Fund Project: The project was supported by the National Natural Science Foundation of China (No.20274034) and the Natural Science Foundation of Gansu Province (3ZS061-A25-036).

The interaction between chitooligosaccharide-5-fluorouracil (COS-5FU) and bovine serum albumin (BSA) was studied by fluorescence spectroscopy. It was found that an energy transfer between COS-5FU and BSA had been occurred. The binding constants were calculated, k_298k=1.175×10^-4L·mol^-1.Based on the mechanism of energy transfer of dipole interaction between the donor and acceptor, the distance between BSA and COS-5FU was determined.
- Chitooligosaccharide-5-fluorouracil,
- BSA,
- fluorescence spectroscopy
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