Citation: Qing Xiang GUO, Zi Zhong LI, Jun WANG, You Cheng LIU. A1HNMR STUDY ON THE FORMATION AND BREAKING OF INTRAMOLECULAR HYDROGEN BONDS OF BILIRUBIN IN CDCl₃-DMSO-d₆ BINARY SOLVENT[J]. Chinese Chemical Letters, ;1993, 4(3): 247-250. shu

A1HNMR STUDY ON THE FORMATION AND BREAKING OF INTRAMOLECULAR HYDROGEN BONDS OF BILIRUBIN IN CDCl₃-DMSO-d₆ BINARY SOLVENT

National Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000

Received Date: 24 August 1992

Fund Project: This research was supported by the National Natural Science Foundation and the State Education Comnission of China.

The formation and breaking of intramolecular hydrogen bonds of bilirubin in CDCl₃-DMSO-d₆ binary solvent have been investigated by means of NMR spectroscopy.The chemical shifts of protons at dipyrrinone lactam C=Oand N-H,Pyrrole N-H,C-5,C-15 and methylene groups of 8,12-propionic acid side-chains changed markedly as a function of composition of the binary solvent.The hydrogen bond formation is dependent on the conformation of propionic acid side-chains.
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