Citation: Xing Tao XUE, De Shui Lü Zhi Chun CHEN, Qi WU, Ying CAI, Xian Fu LIN. Enzyme-catalyzed Transesterification of Unusual Substrate:Synthesis of Acyclovir and L-ascorbic Acid (Vitamin C) Vinyl Esters[J]. Chinese Chemical Letters, ;2003, 14(2): 163-166. shu

Enzyme-catalyzed Transesterification of Unusual Substrate:Synthesis of Acyclovir and L-ascorbic Acid (Vitamin C) Vinyl Esters

Department of Chemistry, Zhejiang University, Hangzhou 310027

Received Date: 20 May 2002

The synthesis of acyclovir and L-ascorbic acid with divinyladipate was performed with alkaline protease from Bacillus subtilis and lipase from Lipozyme (immobilized from Mucor miehei) in different anhydrous organic solvents.Two corresponding derivatives were obtained.
- Alkaline protease,
- lipase,
- transesterification,
- acyclovir,
- vitamin C,
- vinyl ester
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