Citation: WU Qi. ADSORPTION OF PROTEIN ON NANOPARTICLES*[J]. Chinese Journal of Polymer Science, ;1994, 12(4): 323-330. shu

ADSORPTION OF PROTEIN ON NANOPARTICLES*

WU Qi

Received Date: 26 November 1993

The adsorption of protein on nanoparticles was studied by using dynamic light scattering tomeasure the hydrodynamic size of both pure protein and nanoparticles adsorbed with differentamounts of protein. The thickness of the adsorbed protein layer increases as proteinconcentration, but decreases as the initial size of nanoparticles. After properly scaling thethickness with the initial diameter, we are able to fit all experimental data with a single mastercurve. Our experimental results suggest that the adsorbed proteins form a monolayer on the nanoparticle surface and the adsorbed protein molecules are attached to the particle surface at many points through a possible hydrogen-bonding.Our results also indicate that as protein concentration increases,the overall shape of the adsorbed protein molecule continuously changes from a flat layer on the particle surface to a stretched coil extended into water.During the change,the hydrodynamic volume of the adsorbed protein increases linearly with protein concentration.
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