Citation: Ming Wu DING, Rui Jun XU, Jing XU, Yun Feng CHEN. A Selective Synthesis of 2-Alkylamino-5, 6, 7, 8-tetrahydro benzothieno [2, 3-d]pyrimidin-4 (3H)-ones[J]. Chinese Chemical Letters, ;2005, 16(2): 189-192. shu

A Selective Synthesis of 2-Alkylamino-5, 6, 7, 8-tetrahydro benzothieno [2, 3-d]pyrimidin-4 (3H)-ones

Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079

Received Date: 5 January 2004

Fund Project: We gratefully acknowledge financial support of this work by the National Key Project for Basic Research (2003CB114400, 2003CB114406) the National Natural Science Foundation of China (Project No.20102001).

2-Alkylamino-5, 6, 7, 8-tetrahydrobenzothieno [2, 3-d] pyrimidin-4 (3H)-ones 7 were synthesized by a new selective synthetic method, which includes aza-Wittig reaction of iminophosphorane 4 with aromatic isocynate to give carbodiimide 5 and subsequent reaction of 5 with various aliphatic primary amine in the presence of EtO^-Na⁺.
- Benzothieno [2,3-d]pyrimidin-4 (3H)-ones,
- aza-Wittig reaction,
- iminophosphorane,
- carbodiimide,
- synthesis.
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