Two Cytotoxic Eremophilanolides from Senecio tsoongianus

1.
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031;
2.
Department of Food Science, Hangzhou College of Commerce, Hangzhou 310035;
3.
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204

Received Date: 23 February 2004

Fund Project: This work was financed partially by the foundation for Cheung Kong Scholars Program from Zhejiang University, the opening foundation from KIB, CAS, and Chine-France PRA BT01-02. Y. Zhao is grateful to the Chinese Ministry of Education as well as to Mr. Ka-shing Li for the "Cheung Kong Scholars Chair Professorship" at Zhejiang University. Our thanks are due to Dr. F. Gueritte for screening the cytotoxicity of two crude extracts on KB cell line as well as useful discussions.

Two new eremophilanolides, tsoongianolide E and F, were isolated from Senecio tsoongianus. Their structures were elucidated on the basis of NMR and MS spectra. Both of these two compounds showed in vitro cytotoxicity to cultured KB and A-549 cancer cell lines.

Two Cytotoxic Eremophilanolides from Senecio tsoongianus

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