Citation: Jia Xi XU, Meng Shen CAI. Prediction, Synthesis and Antigenicity of the Antigenic Peptides of 26kDa Glutathione S-Transferasc of Schistosoma Japonicum (Sj26)[J]. Chinese Chemical Letters, ;1999, 10(1): 27-28. shu

Prediction, Synthesis and Antigenicity of the Antigenic Peptides of 26kDa Glutathione S-Transferasc of Schistosoma Japonicum (Sj26)

Jia Xi XU ^a ,
Meng Shen CAI ^b

a College of Chemistry and Molecular Engineering, Peking University, Beijing 100871;
b School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083

Received Date: 3 July 1998

Fund Project: Project 29772002 supported by the National Natural Science Foundation of China.

Six antigenic peptides of 26 kDa glutathione S-transferase of Schistosoma japonicum (Sj26) have been predicted according to their hydrophilicity. flexibility, accessibility, charge distribution and β -turn in the secondary structure by the determination of its primary structure and synthesized by solid phase method. All of them showed antigenicity with anti-schistosoma japonicum immunoglobulin polyclonal antibody, anti-Sj-IgG PcAb by Dot-ELISA. Three of them showed good antigenicity. They would serve as candidates of synthetic anti-schistosomal vaccine.
- Schistosoma japonicum,
- glutathione S-transferase,
- antigenic peptide,
- peptide vaccine
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