Citation: Jian Wen JIANG, Ming Zhong CAI. A Facile Stereospecific Synthesis of 1, 3-Enynylsulfides via Sonogashira Coupling of (E)-α-Iodovinyl Sulfides with 1-Alkynes[J]. Chinese Chemical Letters, ;2006, 17(6): 757-760. shu

A Facile Stereospecific Synthesis of 1, 3-Enynylsulfides via Sonogashira Coupling of (E)-α-Iodovinyl Sulfides with 1-Alkynes

Department of Chemistry, Jiangxi Normal University, Nanchang 330027

Received Date: 12 December 2005

Fund Project: We thank the National Natural Science Foundation of China (Project 20462002) and Natural Science Foundation of Jiangxi Province (Project 0420015) for financial support.

(E)-α-Iodovinyl sulfides 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 in piperidine at room temperature in the presence of 5 mol% of Pd(PPh₃)₄ and 10 mol% of CuI to afford the corresponding 1, 3-enynylsulfides 3 stereospecifically in high yields.
- (E)-α-Iodovinyl sulfide,
- 1,3-enynylsulfide,
- Sonogashira coupling,
- terminal alkyne
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