Citation: Guo Qiang HU, Song Qiang XIE, Wen Long HUANG, Hui Bin ZHANG. Synthesis and Antibacterial Activity of 8-Substituted Phenyl-1-pyridin-3-yl-5H-bis[1, 2, 4]triazolo[3, 4-b;4', 3'-d] [1, 3, 4] thiadiazines[J]. Chinese Chemical Letters, ;2005, 16(6): 723-726. shu

Synthesis and Antibacterial Activity of 8-Substituted Phenyl-1-pyridin-3-yl-5H-bis[1, 2, 4]triazolo[3, 4-b;4', 3'-d] [1, 3, 4] thiadiazines

1.
Medicinal College of Henan University, Kaifeng 475004;
2.
China Pharmaceutical University, Nanjing 210009

Received Date: 8 June 2004

Fund Project: We appreciate that this project is supported by the National Natural Science Foundation of China (No. 30070861) and the Science Foundation of Henan University (XK02041).

To find new structural leading compounds for the research of the multidrug resistant of antibacterial agents, five novel 8-substituted phenyl-1-pyridin-3-yl-5H-bis[1, 2, 4] triazolo[3, 4-b;4', 3'-d] thiadiazines were prepared from the corresponding intermediates of 3-(5-substituted phenyl[1,3,4]oxadiazol-2-ylmethylsulfanyl)-5-pyridin-3-yl-[1,2,4]triazol-4-ylamines via intramolecular cyclization and the antibacterial activity in vitro against Gram-postive (G⁺) and Gram negatiye (G^-) bacteria was primarily evaluated.
- Antibiotics,
- triazole,
- thiadiazine,
- synthesis,
- antibacterial agent
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