Citation: Guang Xing WANG, Shu Feng CHEN, Xiao Tian LIANG. Total Synthesis of (±)Chrysotricine[J]. Chinese Chemical Letters, ;1998, 9(4): 357-360. shu

Total Synthesis of (±)Chrysotricine

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 22 December 1997

Fund Project: We thank the National Research Center for Analysis of Drugs and Metabolites for recording of NMR and MS. We are also grateful to Prof. Xiao-Zhang Feng for a sample of the natural chrysotricine.

(±)Chrysotricine 1 was synthesized by a facile route. The key steps in the synthesis were aldol condensation of dilithium salt of harman 4 with 6-methyl-5-hepten-2-one 5 and cyclization of compound 6 using MCPBA. The ¹HNMR spectrum of synthetic product was identical to that of the natural sample.
- (±)chrysotricine,
- aldol condensation,
- dilithium salt of harman
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