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Citation:
Guo Feng ZHAO, Hua Zheng YANG, Lin Xiu WANG, Yong Hong LI. Bioisosterism between Sulfonyl Group and Phosphoryl Group-The Synthesis of New ALS Inhibitors N-(Arylamino Hydroxyl Phosphoryl)-N'-(4,6-Dimethoxypyrimidine-2-yl)ureas[J]. Chinese Chemical Letters,
;1998, 9(8): 723-725.
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In view of the isosterism of sulfonyl group (-SO2-) and phosphoryl group [-P(0)(0R)-, R=H, CH3, C2H5, etc], a new type of ureas, that is, N-phosphoryl-N'-(4,6-dimethoxypyrimidin-2-yl) ureas 2 were synthesized and shown to be a new class of acetolactate synthase (ALS) inhibitors.
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Keywords:
- isosterism,
- bioisosterism,
- sulfonylurea,
- phosphorylurea,
- ALS inhibitors
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