Citation: Wei Gang LU, Cui Xian ZHANG, Jing Yu SU, Long Mei ZENG. Synthesis of 24-Methylene-cholest-5-ene-7-oxo-3β,19-diacetate[J]. Chinese Chemical Letters, ;2005, 16(5): 604-606. shu

Synthesis of 24-Methylene-cholest-5-ene-7-oxo-3β,19-diacetate

School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275

Received Date: 8 June 2004

Fund Project: We are grateful to the National Natural Science Foundation of China (No. 29932030), the National High Technology Development Project (No. 2001AA624030), and the Natural Science Foundation of Guangdong Province (No. 04300569) for financial support for this work.

24-Methylenecholest-5-ene-7-oxo-3β,19-diacetate 5 was synthesized starting from stigmasterol via twelve step reactions in 4.1% overall yield. It can be served as a key intermediate for the synthesis of 24-methylenecholest-5-ene-3β,7β,19-triol 1, a naturally occuring polyhydroxylated sterol with potential biological activity.
- Methylene-cholest-5-ene-3β,7β,19-triol,
- synthesis,
- allylic oxidation,
- PCC/A1₂O₃
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