Citation: Ming SUN, Di Hua SHANG GUAN, Hui Min MA, Li Hua NIE, Xiao Hua LIShao Xiang XIONG. A Novel Fluorescent Probe for Lead Ions[J]. Chinese Chemical Letters, ;2003, 14(10): 1024-1026. shu

A Novel Fluorescent Probe for Lead Ions

Laboratory of Chemical Biology, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080

Received Date: 21 October 2002

Fund Project: This work is financially supported by the NNSF of China (No.20175031No.20035010).

A new fluorescent probe for lead ions, p-nitrophenyl 3H-phenoxazin-3-one-7-yl phosphoric acid (NPPA), has been synthesized by linking resorufin (serving as a fluorophore and electron acceptor) to p-nitrophenol (serving as a fluorescence quencher and electron donor) through phosphodiester bonds. When NPPA was irradiated with light, intramolecular fluorescence self-quenching took place due to the PET (photoinduced electron transfer) from the donor to the acceptor. However, upon addition of Pb^Ⅱ, the phosphate ester bonds in the probe were cleaved and the fiuorophore was released, accompanying the retrievement of fluorescence.
- Fluorescent probe,
- lead,
- phosphodiester,
- hydrolysis
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