Citation: Jing Jiang LIU, Yan Zhong WANG, Rui HAN, Hong Yan LIU. ANTI-CANCER DRUGS COMPOSED OF NONNOBLEMETAL COORDINATION COMPOUNDS[J]. Chinese Chemical Letters, ;1995, 6(9): 771-772. shu

ANTI-CANCER DRUGS COMPOSED OF NONNOBLEMETAL COORDINATION COMPOUNDS

a Nankai University, Tianjin 300071;
b Institute of Materia Medica, Beijing 100050

Received Date: 7 February 1995

Fund Project: This work is supported by The National Natural Science Foundation of China.

The designed and synthesized compounds are the coordination compounds between MCl₂(M=Cu, Co, Mn) and the Mannich base made by methyl piperizine and tetracycline hydrochloride.The cancer cells of HCT-8, KB, A2780, MGC80-1 and Bel7402 are significantly inhibited by the drugs in vitro.The inhibition ratio of S-180 tumor by the compound of M=Cu is 30% on 10mg/kg level of feed from the in vivo experiments of female white mice.
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