Citation: Chun Yan XU, Ming Zhi HUANG. An Approach to New Water-soluble Oligo(ethylene glycol) Camptothecin Analogues by 1,3-Dipolar Cycloaddition[J]. Chinese Chemical Letters, ;2006, 17(7): 883-886. shu

An Approach to New Water-soluble Oligo(ethylene glycol) Camptothecin Analogues by 1,3-Dipolar Cycloaddition

College of Materials Science and Technology, Beijing University of Chemical Technology, Beijing 100029

Received Date: 28 February 2006

Combined with an effective copper-catalyzed triazole-forming reaction, a series of novel camptothecin derivatives were synthesized. Incorporating oligo(ethylene glycol) chains into the derivatives enhanced their water-solubility when compared to the parent compound (up to 55-fold).
- Click chemistry,
- 20(S)-camptothecin,
- water-soluble derivatives
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