Citation: PIAO Aichih, SUN Shumen. SYNTHESIS OF OLIGOMERS CONTAINING 5-FLUOROURACIL[J]. Chinese Journal of Polymer Science, ;1983, 1(2): 196-199. shu

SYNTHESIS OF OLIGOMERS CONTAINING 5-FLUOROURACIL

PIAO Aichih ,
SUN Shumen

Received Date: 29 December 1982

The condensation oligomers of 5-fluorouracil were prepared by reaction of 2,4-bis-(trimethyl-silyloxy)-5-fluoropyrimidine) with various dicarboxylic chlorides, e.g.The structures of obtained oligomers were characterized by IR and the oligomers were then hydrolyzed in acid, alkaline and neutral media at room temperature respectively. The amount of 5-fluorouracil released was quantitated by measuring its UV absorbance at 265.5nm. However in the case of oligomers containing phenylene moiety, 5-fluorouracil was not detected when the hydrolysis was conducted in acid or neutral medium,while in the case of oligomers containing methylene moiety,hydrolysis proceeded easily in acid,alkaline and neutral media.
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