Citation: Qing DAI, Hua WO, Ru Yu CHEN. A Facile Synthesis of N-Substituted Spirocyclic Diester of α-Aminophosphonic Acid[J]. Chinese Chemical Letters, ;1998, 9(1): 10-12. shu

A Facile Synthesis of N-Substituted Spirocyclic Diester of α-Aminophosphonic Acid

Institute and State's Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received Date: 9 June 1997

Fund Project: This project was supported by the National Natural Science Foundation of China and Nankai University Science and Teclinology Development Foundation.

A simple and direct method for preparation of N-substituted spirocyclic diester of □-amino phosphonic acid (4) in high yield is introduced. The reaction consists of the three-component reaction of phenylurea (1), an aromatic aldehyde (2), and 3,9-dichloro-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5,5] undecane (3) in anhydrous benzene.
- Spirocyclic diester,
- α-aminophosphonic acid
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