Citation: Jing Shan SHEN, Li Jun LEI, Hai Fang MAO, Jian Feng LI, Ru Yun JI. Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues[J]. Chinese Chemical Letters, ;2001, 12(11): 951-954. shu

Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues

1.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031;
2.
Shanghai Jahwa Fine Chemicals Co. Ltd, Shanghai 200040

Received Date: 10 April 2001

Fund Project: This program was supported by the Shanghai Development Fund of Science and Technology.

5-Substituted hexahydro-1H-1,4-diazepine analogues were synthesized starting from N, N'-dibenzyl-1, 2-ethylenediamine and methyl 2, 4-dibromide butyrate through nucleophilic substitution, reduction, chlorination, debenzylation and amidation. Bioactivity tests showed that 9a had the highest agonist activity.
- Substituted hexahydro-lH-1,
- 4-diazepine analogues,
- synthesis,
- bioactivity
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