Citation: Zi Yi ZHANG, Yu Xiang LIANG, Zuo Wu GUAN. Studies on Semisynthesis and Anibacterial Activity of 7 β-(5-Methyl-1-Aryl-1H-1,2,3-Triazoly-4-Carboxamido) Cephalosporins[J]. Chinese Chemical Letters, ;1997, 8(4): 295-298. shu

Studies on Semisynthesis and Anibacterial Activity of 7 β-(5-Methyl-1-Aryl-1H-1,2,3-Triazoly-4-Carboxamido) Cephalosporins

a National Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 73000;
b Institute of Applied Pharmacy, Beijing Medical University, Beijing 100083

Received Date: 17 December 1996

Nine new derivatives of 7 β-(5-methyl-1-aryl-1H-1,2,3-triazoly-4-carboxamido) cephalosporins were synthesized by acylation of 7 β-amino group of 7-ACA,7-ADCA and 7-ACT with 5-methyl-1-aryl-1H-1,2,3-triazoly-4-formyl chloride.The structure of the compounds were confirmed by elementary analysis IR,¹HNMR and FAB-MS.Some of them showed significant antibacterial activity.
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