Citation: Wei Ming XU, Lu Ling WU, Xian HUANG. Solid Phase Synthesis of 1, 4-Disubstituted 1, 2, 3-Triazole from Polystyrene-supported Selenium Resin[J]. Chinese Chemical Letters, ;2006, 17(5): 603-605. shu

Solid Phase Synthesis of 1, 4-Disubstituted 1, 2, 3-Triazole from Polystyrene-supported Selenium Resin

1.
Department of Chemistry, Zhejiang University(Campus Xixi), Hangzhou 310028;
2.
Center of Analysis and Measurement, Zhejiang University, Hangzhou 310028

Received Date: 24 October 2005

Fund Project: We are grateful to the National Natural Science Foundation of China (No. 20332060) and the Natural Science Foundation of Zhejiang Province (No. Y405407).

We report here a solid-phase synthesis of 1, 4-disubstituted 1, 2, 3-triazole using polystyrene-supported selenium resin. The resin used here not only works as a simple linker, but also assists the crucial α-alkylation reaction and selenoxide syn-elimination, which ensures the purity of the products.
- Solid-phase synthesis,
- 1,3-dipolar cycloaddition,
- α-alkylation reaction,
- 1,2,3-triazole
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