Citation: Zi Chen LI, Wei JIN, Fu Mian LI. Synthesis of Cholesterol Derivative with Amino Acid as Hydrophilic Group and the Vesicles Prepared Therefrom[J]. Chinese Chemical Letters, ;1999, 10(12): 1003-1006. shu

Synthesis of Cholesterol Derivative with Amino Acid as Hydrophilic Group and the Vesicles Prepared Therefrom

College of Chemistry Peking University Beijing 100871

Received Date: 17 March 1999

Fund Project: This work was partially supported by the National Natural Science Foundation of China (#59603004) and Ministry of Education of China.

Three single chain amphiphilic cholesterol derivatives with amino acid as hydrophilic groups,Ⅰ, Ⅱ and Ⅲ, were synthesized. When they were hydrated in water, they can all form lamellae structures as evidenced by DSC measurement. The lamellae states of Ⅱ and Ⅲ can be converted to vesicles upon ultrasonication of the diluted aqueous solutions. The vesicles showed very slow release rate of the encapsulated water-soluble dyes, indicating that they are stable and belong to the least permeable vesicles.
- Vesicles,
- amphiphiles,
- amino acid,
- cholesterol
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