Citation: Zhi YANG, Gu Ping TANG. Poly(ethylenimine)-grafted-poly[(aspartic acid)-co-lysine]: A Non-viral Polymer with Potential for DNA Delivery[J]. Chinese Chemical Letters, ;2004, 15(1): 37-40. shu

Poly(ethylenimine)-grafted-poly[(aspartic acid)-co-lysine]: A Non-viral Polymer with Potential for DNA Delivery

Zhi YANG ,
Gu Ping TANG

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031

Received Date: 23 December 2002

Fund Project: This project was supported by the National Natural Science Foundation of China, No. 39970879

A biodegradable gene transfer vector, poly(ethylenimine)-grafted-poly[(aspartic acid)-co-lysine] has been developed by thermal polycondensation of aspartic acid and lysine, and branch poly(ethylenimine) (Mw less than 600) was grafted to the backbone. The polymer was characterized by ¹H NMR. It appeared lower cytotoxity compared to poly(ethylenimine) (25KDa), which was quantified by MTT assay. Electrophoresis indicated that the polymer could retardate DNA at N/P ratio 1.2-1.8 (w/w). Transfection efficiency of the complexes was studied in NT2 cell lines. It was 1.5 fold higher than molecular weight PEI (Mw=25KDa).
- Poly(ethylenimine)-grafted-goly[(aspartic acid)-co-lysine],
- biodegradable,
- cytotoxicity,
- transfection efficiency
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