Citation: Jing Xu GONG, Yu Bin FENG, Feng WANG, Yan Guang WANG, Hai Bo LI, Yi Hang WU, Xiao Jiang HAO, Xiu Mei WU, Hua BAI, Joachim STÖCKIGT, Yu ZHAO. Preparation of (±)-5, 6, 7-Trioxygenated Dihydrofiavonols and Evaluation of their Superoxide Radical Scavenging Activity[J]. Chinese Chemical Letters, ;2006, 17(4): 449-452. shu

Preparation of (±)-5, 6, 7-Trioxygenated Dihydrofiavonols and Evaluation of their Superoxide Radical Scavenging Activity

1.
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031;
2.
The Key Laboratory of Chemistry of Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550022;
3.
Zhejiang Hisun Naturelite Pharmaceutical R & D Co., Ltd., Hangzhou 310007;
4.
Lehrstuhl für Pharmazeutische Biologie, Institut für Pharmazie, Johannes-Gutenberg Universität Mainz, D-55099 Mainz, Germany

Received Date: 12 September 2005

Fund Project: This work is financially supported by the Special 985 Fundation from Zhejiang University and DAAD-CSC PPP project (CSC [2004] 3067).

The synthesis of (±)-5, 6, 7-trioxygenated dihydroflavonols was carried out. All synthetic compounds were passed through superoxide radical scavenging activity in vitro.Compounds 1e and 1g exhibited significant bioactivity with the inhibitory rates of 68.1% and 80.9% at 40μg/mL, respectively.
- Dihydroflavonol,
- (±)-5,6,7-trioxygenated-dihydroflavonols,
- total synthesis,
- antioxidant,
- superoxide radical scavenging
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