Citation: Ai Hua NIE, Jun Hai XIAO, Hong Ying LIU, Li Li WANG, Song LI. Drug Discovery Based on the Structure of FKBPs:Design, Synthesis and Evaluation of L-1, 4-Thiazane-3-carboxylic Acid Derivatives as Neuroimmunophilin Ligands[J]. Chinese Chemical Letters, ;2005, 16(2): 163-166. shu

Drug Discovery Based on the Structure of FKBPs:Design, Synthesis and Evaluation of L-1, 4-Thiazane-3-carboxylic Acid Derivatives as Neuroimmunophilin Ligands

Beijing Institute of Pharmacology and Toxicology, Beijing 100850

Received Date: 22 December 2003

Fund Project: The authors thank the National 863 Program Foundation (2002A A233051) of China for support.

Based on the structure of FK506, FKBP12 and calcineurin complex and the interactive characteristics of small molecular ligands with FKBPs, a series of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands was designed and synthesized. The results of evaluation show that compound N308 has a great promise as a candidate of neuroprotective and neuroregenerative agent.
- FKBPs,
- neuroimmunophilin ligands,
- design,
- synthesis.
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