Citation: Li BAI, Ru Yu CHEN, Yuan Yuan ZHU. Synthesis of Polyphosphonates Containing 5-Flouro-N¹-furanyl-N³-glyceroalkyl-uracil and Formyl Groups[J]. Chinese Chemical Letters, ;2002, 13(1): 28-32. shu

Synthesis of Polyphosphonates Containing 5-Flouro-N¹-furanyl-N³-glyceroalkyl-uracil and Formyl Groups

Institute and National Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received Date: 8 May 2001

Fund Project: This project was supported by the National Natural Science Foundation of China.

A series of novel polyphosphonates containing 5-flouro-N¹-furanyl-N³-glyceroalkyl-uracil and formyl groups was synthesized by the condensation of 3-(ω-(1'-furanyl-5-flourouracil-3-yl) alkoxy)-1, 2-dihydroxy propane with phosphonyl dichloride.The products were characterized by IR, ¹H NMR, ³¹P NMR, M,and elementalanalysis.The resultsof bioassay show that compound 8a possesses potential anticancer activity.
- Polyphosphates,
- furanyl,glyceryl,
- 5-flourouracil,
- formyl
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