Citation: Ren Xi ZHUO, Yan Jun FU, Jun LIAO. Synthesis, Relaxivity and Biodistribution of Novel Magnetic Resonance Imaging (MRI) Contrast Agents:Polylysine (Gd-DTPA/DOTA) with Pendent Galactose Moieties as Hepatocyte-targeting Groups[J]. Chinese Chemical Letters, ;1997, 8(2): 157-160. shu

Synthesis, Relaxivity and Biodistribution of Novel Magnetic Resonance Imaging (MRI) Contrast Agents:Polylysine (Gd-DTPA/DOTA) with Pendent Galactose Moieties as Hepatocyte-targeting Groups

Dept. of Chemistry, Wuhan University, Wuhan 430072

Received Date: 11 June 1996

Fund Project: This work was supported by the National "863 Plan". The authers would like to thank Mr. Zong-Jie Shi for his assistance in the biodistribution experiment.

DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (DP 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA.The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging.These new polymer conjugates were characterized by FT-IR,ICP-AES,UV-Vis spectrophotometry and elemental analysis.Their in vitro spin-lattice relaxivity and body distribution in mice were investigated.
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