Citation: Ye Feng TANG, Zhan Zhu LIU, Shi Zhi CHEN. Study on the Total Synthesis of Et 743 and its Analogues:Synthesis of a Tricyclic Intermediate and its 11-Epimer[J]. Chinese Chemical Letters, ;2003, 14(10): 997-998. shu

Study on the Total Synthesis of Et 743 and its Analogues:Synthesis of a Tricyclic Intermediate and its 11-Epimer

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union MedicalCollege, Beijing 100050

Received Date: 8 October 2002

The tricyclic compound 1, a key intermediate of the pentacyclic core of Et 743 and its analogues, was synthesized. Its 11-epimer was found as the product of racemization when BOP was used as the coupling agent, but not when BOP-Cl used in the same reaction. The stereochemistry of both isomers was confirmed on basis of the 1H NMR and NOE-difference spectra.
- Et 743,
- tricyclic compound,
- synthesis,
- stereochemistry
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