Citation: Bin HU, Kun XIAO, Jing Kang SHEN. A Mild and Efficient Synthesis of Chiral N-Boc-α-aminoaldehydes[J]. Chinese Chemical Letters, ;2006, 17(9): 1162-1164. shu

A Mild and Efficient Synthesis of Chiral N-Boc-α-aminoaldehydes

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203

Received Date: 23 March 2006

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 30230400), "863" Hi-Tech Program of China (No. 2004 AA2 Z3781) and the State Key Program of Basic Research of China(No. 2004GB518907).

A series of chiral N-Boc-α-aminoaldehydes were synthesized in good yields and high purity via esterification of Boc-L-amino acids followed by reduction with sodium bis (2-methoxyethoxy)aluminum hydride.
- Aminoaldehyde,
- reduction,
- sodium bis(2-methoxyethoxy)aluminum hydride,
- ester,
- amino acid
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