Citation: Shang Hui HU, Xu Fang TIAN, Wen Yi HE, Man KONG, Di An SUN, Qi Cheng FANG. Microbial Transformation of Taxoids and Synthesis of Taxoids ith an Oxetane Ring[J]. Chinese Chemical Letters, ;1998, 9(1): 39-43.
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Microbial transformation of taxoids was investigated:taxoid 2 was transformed into 1β and 14β hydroxylated derivatives 3 and 4; unnatural taxoid 6 was transformed into 1β-hydroxy derivative 7 and 11(15→1) abeotaxane 8. Taxoids with an oxetane ring, 11-13 were synthesized from 1 via chemical reactions.
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Keywords:
- Taxoid,
- abeotaxane,
- oxetane ring,
- chemoenzymatic method
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