Citation: Qing Xiang XIANG, Hong ZHOU, Xin Yan WANG, Xiao Qi YU, Jing Ku BAO, Ru Gang XIE. Interaction between Bifunctional Dioxo Macrocyclic Polyamine Co(Ⅱ) Complex and DNA in Metallomicellar System[J]. Chinese Chemical Letters, ;2002, 13(3): 223-226. shu

Interaction between Bifunctional Dioxo Macrocyclic Polyamine Co(Ⅱ) Complex and DNA in Metallomicellar System

1.
Department of Chemistry, Sichuan University, Chengdu 610064;
2.
College of Life Science, Sichuan University, Chengdu 610064

Received Date: 6 July 2001

Fund Project: We are thankful to the National Natural Science Foundation of China for financial support (No. 29872027).

The cleavage of DNA (pUC₁₈) by lipophilic macrocyclic polyamine Co(Ⅱ) complex was investigated in metallomicellar system. The results showed that the conversion of plasmid DNA (pUC₁₈) increases with the increase of the concentration of complex under physiological conditions.
- Bifunctional dioxo macrocyclic polyamine,
- complex,
- micellar system,
- cleavage of DNA
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