Citation: Guang Disn HAN, Hong Yau WEN. A NEW METHOD FOR THE AROMATIZATION OF 18-METHYL-ESTRA-4(5), 9(10)-DIEN-3,17-DIONE[J]. Chinese Chemical Letters, ;1992, 3(6): 419-420. shu

A NEW METHOD FOR THE AROMATIZATION OF 18-METHYL-ESTRA-4(5), 9(10)-DIEN-3,17-DIONE

Institute of Materia Medica Chinese Academy of Medical Sciences Beijing 100050

Received Date: 31 January 1992

An aromatization reaction was found when 18--methyl--estra--4(5),9(10)--dien--3, 17--dione(6) was treated with triethyl orthoforrnate in dioxane in thepresence of catalytic amount of p--toluenesulfonic acid (TsOH), and 18--methyl--9(11)--dehydroestrone--3--ethyl ether (8) was obtained in 70% yield.The mechanism wasfound to be a process of etherification--oxidation reaction
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