Citation: Nian Ping FENG, Zheng Xing ZRANG, Deng Kui AN, Wen Long HUANG, Guang Ji WANG, Xiu Wen HAN, Xin He BAO. Identification of the Metabolite of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in Rat Bile by LC/MS and LC/NMR[J]. Chinese Chemical Letters, ;1997, 8(6): 515-518. shu

Identification of the Metabolite of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in Rat Bile by LC/MS and LC/NMR

a China Pharmaceutical University, Nanjing 210009;
b Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023

Received Date: 20 January 1997

The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB),a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile.A metabolite and unchanged CTHB were found in the bile.Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR.
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