Citation: Xiao Yu ZHANG, Feng Hua CHEN, Ping Hui WEI, Jia Zuan NI. Studies on the Effects of Epimedium Extract on Erythrocytes[J]. Chinese Chemical Letters, ;2006, 17(8): 1105-1108. shu

Studies on the Effects of Epimedium Extract on Erythrocytes

1.
Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan University, Hebei 066004;
2.
Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022

Received Date: 13 February 2006

The effect of Epimedium extract (EE) on erythrocytes was investigated by atomic force microscopy (AFM). The images of the surface structures showed clear concave and progressive increase of surface roughness of erythrocyte after incubation with EE at concentration of 0.2 or 0.05 g/L, far below its critical hemolytic levels. The AFM results also indicated that the granules of the fine surface structure increased, which caused by aggregation of membrane protein. Further study showed that the change in surface topography of erythrocyte membrane might be connected with the increase of intracellular free Ca²⁺ induced by EE.
- AFM,
- Epimedium extract (EE),
- erythrocyte,
- intracellular free Ca²⁺
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