Citation: Xiao Quan LU, Xi Bin ZHOU, Jing Wan KANG, Zai Xin GENG, Jin Zhang GAO. Studies on the Erythromycin-Modified Glassy Carbon Electrod and Interaction with DNA[J]. Chinese Chemical Letters, ;1999, 10(4): 307-310. shu

Studies on the Erythromycin-Modified Glassy Carbon Electrod and Interaction with DNA

Institute of Chemistry, Northwest Normal University, Lanzhou 730070

Received Date: 31 August 1998

Fund Project: This subject is supported by the Natural Science Foundation of Gansu Province.

The chemically modified electrode (CME) which was constructed by covalent attaching erythromycin (ERM) to the glassy carbon (GC) surface was investigated in Tris-HCI buffer (pH=6.0) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). In the potential range of -0.5~0.4V, CME yields a pair of stable redox wave. It is the carbonyl group of the ERM molecule immobilized on the GC surface that undergoes two electron redox process involving two protons. The interaction of CME with DNA was also studied by DPV. The CME shows the same interaction with DNA as that in the solution. And the result was proved by fluorescence.
- Erthromycin,
- chemically modified electrode,
- voltammetry,
- interaction,
- DNA
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