Citation: HUANG Tong-Hui, CHEN Hua, CHEN Jie, ZHANG Ai-Dong. Syntheses, Crystal Structures, and Biological Activities of Two 5-Pyrimidinyl-1,2,4-oxadiazoles[J]. Chinese Journal of Structural Chemistry, ;2014, 33(10): 1455-1459. shu

Syntheses, Crystal Structures, and Biological Activities of Two 5-Pyrimidinyl-1,2,4-oxadiazoles

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a School of Pharmacy, Xuzhou Medical College, Xuzhou 221004, China;
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b Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China

Corresponding author: HUANG Tong-Hui,
Received Date: 28 March 2014
Available Online: 10 July 2014
Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 81302629, 21172088) (Nos. 81302629, 21172088)

Two 5-pyrimidinyl-1,2,4-oxadiazoles were synthesized through two different routes and their structures were characterized by single-crystal X-ray diffraction, NMR and MS. Compound 3, 5-(2-chloro-4-methyl-6-phenylpyrimidin-5-yl)-3-phenyl-1,2,4-oxadiazole, crystallizes in orthorhombic, space group Pbca with a=19.1575(11), b=8.2115(5), c=21.2035(12) Å, V=3335.6(3) Å³ and Z=4. Compound 6, 5-(2,6-dichloropyrimidin-4-yl)-3-phenyl-1,2,4-oxadiazole, crystallizes in monoclinic space group Pn with a=8.4275(13), b=5.4088(8), c=13.493(2) Å, β=99.768(3)°, V=4658.6(6) Å³ and Z=8. Preliminary bioassay indicated that the two title compounds had good herbicidal activities.
- synthesis,
- crystal structure,
- herbicidal activity,
- 5-pyrimidinyl-1,2,4-oxadiazole
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