Citation: CAI Zhi-Qiang, MA Wei-Ying, LIU Ju, HU Zhi-Quan, HOU Ling, WANG Jian-Ya. Synthesis, Crystal Structure and Biological Activity of a New 4,5-Diaryl-1H-imidazole Derivative[J]. Chinese Journal of Structural Chemistry, ;2014, 33(9): 1383-1387. shu

Synthesis, Crystal Structure and Biological Activity of a New 4,5-Diaryl-1H-imidazole Derivative

1.
a School of Petrochemical Engineering, Shenyang University of Technology, Liaoyang 111003, China;
2.
b College of Pharmacy, Liaoning University, Shenyang 110036, China

Corresponding author: CAI Zhi-Qiang,
Received Date: 19 February 2014
Available Online: 12 May 2014
Fund Project:

A new 4,5-diaryl-1H-imidazole was synthesized and characterized by ¹H NMR, ESI-MS, elemental analysis and FT-IR. The crystal structure of the title compound (C₁₉H₁₆C₁₂N₂O₂, M_r=375.24) has been determined by single-crystal X-ray diffraction. Crystal parameters:monoclinic system, space group P2₁/n, a=14.349(3), b=8.7918(18), c=15.352(3) Å, β=108.56(3)°, V=1836.1(6) Å³, Z=4, F(000)=776, Dc=1.357 g/cm³, μ=0.368 mm^-1, the final R=0.0502 and wR=0.1066 for 2324 observed reflections with I > 2σ(I). A total of 16117 reflections were collected, of which 3615 were independent (R_int=0.0595). The preliminary bioassay suggested that the title compound exhibits distinct effective inhibition on the proliferation of cancer cell lines.
- 4,5-diaryl-1H-imidazole,
- anti-cancer activity,
- synthesis,
- crystal structure
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