Citation: WU Li-Rong, HUANG Li-Ying, LIN Zhen-Hua. Study on the Synthesis and in vitro Photodynamic Anti-cancer Activity of Tetra(trifluoroethoxy) Germanium Phthalocyanine[J]. Chinese Journal of Structural Chemistry, ;2014, 33(7): 1081-1090. shu

Study on the Synthesis and in vitro Photodynamic Anti-cancer Activity of Tetra(trifluoroethoxy) Germanium Phthalocyanine

a.
a. College of Pharmacy, Fujian Medical University, Fuzhou 350004, China;
b.
b. Quanzhou Medical College, Quanzhou 362010, China;
c.
c. 2nd Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China

Corresponding author: HUANG Li-Ying,
Received Date: 6 December 2013
Available Online: 20 May 2014
Fund Project: Supported by the Natural Science Foundation of Fujian Province (2012J01368) (2012J01368)

The synthesis and in vitro photodynamic anticancer activity of a new photosensitizer, tetra(trifluoroethoxy) germanium phthalocyanine (GePcF), were studied. GePcF was characterized by UV-Vis, IR, MS and elemental analysis. The in vitro photodynamic activity of GePcF was studied by MTT. IC₅₀ of GePcF for SW480 cells of human colonic adenocarcinoma and HeLa cells of cervical cancer were 36.53 and 45.78 μmol/L, respectively. GePcF as a photosensitizer may be used to treat cancers due to its photodynamic anticancer activity.
- tetra(trifluoroethoxy) germanium phthalocyanine,
- synthesis,
- characterization,
- photodynamic activity
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