Citation: YANG Yan-Jun, SHA Cong-Wei, CHEN Mei-Guo, HU Ling. Extraction and Crystal Structure of Physalin B[J]. Chinese Journal of Structural Chemistry, ;2014, 33(5): 795-800. shu

Extraction and Crystal Structure of Physalin B

a.
a. Guangdong Institute of Chinese Materia Medica, Guangdong Food and Drug Vocational College, Guangzhou 510520, China;
b.
b. Guangdong Provincial Institute of Biological Products and Materia Medica, Guangzhou 510440, China

Corresponding author: YANG Yan-Jun,
Received Date: 25 July 2013
Available Online: 14 March 2014
Fund Project: and Guangdong Natural Science Foundation (No. 9151063201000036,S2013010013484) (No. 2011B031700072)

The title compound of physalin B (C₂₈H₃₂O₉), a main active physalin of Physalis angulata L, was isolated from the whole plant of Physalis angulata L, and characterized by X-ray diffraction analysis. It crystallizes in the monoclinic system, space group P2₁ with C₂₈H₃₂O₉, a=12.4996(2), b=14.35620(10), c=14.75190(10)Å, V=2607.97(5)Å³, Z=4, D_c=1.382 mg/cm³, M_r=542.56, F(000)=1152, and μ=0.870 mm^-1. The final R=0.0389 and wR=0.1037 for 47670 observed reflections (I>2σ(I)). The rigid molecule consists of eight fused rings involving two lactones. There are two C₂₈H₃₂O₉ molecules in an symmetric unit, and the title compound is stacked into a 3D layer structure through hydrogen bonds. In the 5~20 μmol/L range, physalin B can significantly inhibit the secretion of inflammatory cytokines TNF-α and IL-6 on RAW264.7 cells. The results suggest that physalin B has anti-inflammatory activity in vitro.
- physalin B,
- crystal structure,
- Physalis angulata L,
- physalin
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