Citation: De Xin WANG, Gui Shen LU. DCHA AS A NEW REAGENT FOR THE ESTERIFICATION OF OBSTINATED AMINO ACIDS BY THE MERRIFIELD'S RESIN[J]. Chinese Chemical Letters, ;1991, 2(4): 289-290. shu

DCHA AS A NEW REAGENT FOR THE ESTERIFICATION OF OBSTINATED AMINO ACIDS BY THE MERRIFIELD'S RESIN

De Xin WANG ,
Gui Shen LU

Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050

Received Date: 19 December 1990

The obstinated amino acid,Boc-Asn(or Boc-Gln),was directly anchored onto the Merrifield's resin using DCHA as the base in present reaction.The yield(71.88%)of Boc-Asn-OCH₂-resin was much better than those(0-33.5%)using Cs₂CO₃,KOH,KF.DEA and TEA as the base.which are efficient reagents for other amino acids in the same reaction.
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