Citation: Yong-zhi Qiu, Dou-yong Min, Chi Ben, Jian Shen, Qiang Chen, Si-cong Lin. A NOVEL ZWITTERIONIC SILANE COUPLING AGENT FOR NONTHROMBOGENIC BIOMATERIALS[J]. Chinese Journal of Polymer Science, ;2005, 23(6): 611-617. shu

A NOVEL ZWITTERIONIC SILANE COUPLING AGENT FOR NONTHROMBOGENIC BIOMATERIALS

Corresponding author: Si-cong Lin,
Received Date: 5 October 2004
Revised Date: 5 March 2005

A novel silane coupling agent bearing sulfobetaine group, N,N-diethyl-N-(3-sulfopropyl)-aminopropyl- trimethoxysilane (DESATS), was first designed, synthesized and characterized. Its solution property was studied by means of dynamic light scattering. DESATS was successfully bonded onto the surface of the glass and proved by ESCA. Platelet adhesion assay in vitro indicated that the nonthrombogenicity of glass slide modified with DESATS is greatly improved.
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