Citation: Guang Yu XU, Chun Hao YANG, Bo LIU, Xi Han WU, Yu Yuan XIE. Catechol-Bisphosphonate Conjugates: New Potential Chelating Agents for Metal Intoxication Therapy[J]. Chinese Chemical Letters, ;2004, 15(12): 1403-1406. shu

Catechol-Bisphosphonate Conjugates: New Potential Chelating Agents for Metal Intoxication Therapy

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai 201203

Received Date: 9 October 2003

In a quest for better chelating therapy drugs for the treatment of intoxication by Fe, Al, or actinides, two new series of mixed catechol-bisphosphonate through amide linkage were synthesized.Benzyl group was used as protecting group to avoid the breakage of amide by acid hydrolysis or imcomplete reaction in silylation-dealkylation using bromotrimethylsilane.
- Bisphosphonates,
- catechol,
- chelating agents,
- metal intoxication therapy
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