Citation: Gang LU, Robert FRANZÉN, Xiao Jing YU, You Jun XU. Synthesis of Flurbiprofen via Suzuki Reaction Catalyzed by Palladium Charcoal in Water[J]. Chinese Chemical Letters, ;2006, 17(4): 461-464. shu

Synthesis of Flurbiprofen via Suzuki Reaction Catalyzed by Palladium Charcoal in Water

1.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016;
2.
Institute of Materials Chemistry, Tampere University of Technology, Korkeakoulunkatu 8, Tampere, FIN-33720, Finland

Received Date: 19 September 2005

Fund Project: We are grateful to Liaoning Natural Science Foundation for the Talent Doctors Fund (No. 20041037) and Magnus Ehrnrooths Foundation of Finland for the financial supports.

Flurbiprofen 1, an excellent nonsteroidal an tiinflammatory drug, was synthesized in 5steps in 69% overall yield. The key step of constructing the biaryl fragment was successfully achieved via Pd/C-catalyzed Suzuki coupling reaction in water using sodium tetraphenylborate as phenylation reagent.
- Flurbiprofen,
- Suzuki coupling,
- Pd/C,
- sodium tetraphenylborate
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